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Histone deacetylase inhibition enhances the therapeutic effects of methotrexate on primary central nervous system lymphoma
BACKGROUND: Polyglutamylation is a reversible protein modification that commonly occurs in tumor cells. Methotrexate (MTX) in tumor cells is polyglutamylated and strongly binds to dihydrofolate reductase (DHFR) without competitive inhibition by leucovorin. Therefore, tumor cells with high polyglutam...
Shranjeno v:
| izdano v: | Neurooncol Adv |
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| Main Authors: | , , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
Oxford University Press
2020
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7415262/ https://ncbi.nlm.nih.gov/pubmed/32793886 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/noajnl/vdaa084 |
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