Histone deacetylase inhibition enhances the therapeutic effects of methotrexate on primary central nervous system lymphoma

BACKGROUND: Polyglutamylation is a reversible protein modification that commonly occurs in tumor cells. Methotrexate (MTX) in tumor cells is polyglutamylated and strongly binds to dihydrofolate reductase (DHFR) without competitive inhibition by leucovorin. Therefore, tumor cells with high polyglutam...

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Vydáno v:Neurooncol Adv
Hlavní autoři: Fujimoto, Kenji, Shinojima, Naoki, Hayashi, Mitsuhiro, Nakano, Tomoyuki, Ichimura, Koichi, Mukasa, Akitake
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2020
Témata:
Basic and Translational Investigations
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7415262/
https://ncbi.nlm.nih.gov/pubmed/32793886
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/noajnl/vdaa084
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