Differences in genetic and epigenetic alterations between von Hippel–Lindau disease–related and sporadic hemangioblastomas of the central nervous system

BACKGROUND: Although inactivation of the von Hippel–Lindau gene (VHL), located on chromosome 3p25, is considered to be a major cause of hemangioblastomas (HBs), the incidence of biallelic inactivation of VHL is reportedly low. The aim of this study was to determine the prevalence of VHL alterations...

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Dades bibliogràfiques
Publicat a:Neuro Oncol
Autors principals: Takayanagi, Shunsaku, Mukasa, Akitake, Tanaka, Shota, Nomura, Masashi, Omata, Mayu, Yanagisawa, Shunsuke, Yamamoto, Shogo, Ichimura, Koichi, Nakatomi, Hirofumi, Ueki, Keisuke, Aburatani, Hiroyuki, Saito, Nobuhito
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2017
Matèries:
Basic and Translational Investigations
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5570160/
https://ncbi.nlm.nih.gov/pubmed/28379443
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nox034
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