Differences in genetic and epigenetic alterations between von Hippel–Lindau disease–related and sporadic hemangioblastomas of the central nervous system

BACKGROUND: Although inactivation of the von Hippel–Lindau gene (VHL), located on chromosome 3p25, is considered to be a major cause of hemangioblastomas (HBs), the incidence of biallelic inactivation of VHL is reportedly low. The aim of this study was to determine the prevalence of VHL alterations...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Neuro Oncol
Hauptverfasser: Takayanagi, Shunsaku, Mukasa, Akitake, Tanaka, Shota, Nomura, Masashi, Omata, Mayu, Yanagisawa, Shunsuke, Yamamoto, Shogo, Ichimura, Koichi, Nakatomi, Hirofumi, Ueki, Keisuke, Aburatani, Hiroyuki, Saito, Nobuhito
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2017
Schlagworte:
Basic and Translational Investigations
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5570160/
https://ncbi.nlm.nih.gov/pubmed/28379443
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nox034
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