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Signaling via the p75 neurotrophin receptor facilitates amyloid-β-induced dendritic spine pathology

Synapse and dendritic spine loss induced by amyloid-β oligomers is one of the main hallmarks of the early phases of Alzheimer’s disease (AD) and is directly correlated with the cognitive decline typical of this pathology. The p75 neurotrophin receptor (p75(NTR)) binds amyloid-β oligomers in the nM r...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Patnaik, Abhisarika, Zagrebelsky, Marta, Korte, Martin, Holz, Andreas
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2020
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7415136/
https://ncbi.nlm.nih.gov/pubmed/32770070
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-70153-4
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