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Signaling via the p75 neurotrophin receptor facilitates amyloid-β-induced dendritic spine pathology

Synapse and dendritic spine loss induced by amyloid-β oligomers is one of the main hallmarks of the early phases of Alzheimer’s disease (AD) and is directly correlated with the cognitive decline typical of this pathology. The p75 neurotrophin receptor (p75(NTR)) binds amyloid-β oligomers in the nM r...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Veröffentlicht in:Sci Rep
Hauptverfasser: Patnaik, Abhisarika, Zagrebelsky, Marta, Korte, Martin, Holz, Andreas
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2020
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7415136/
https://ncbi.nlm.nih.gov/pubmed/32770070
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-70153-4
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