Comparative Target Analysis of Chlorinated Biphenyl Antimicrobials Highlights MenG as a Molecular Target of Triclocarban

Triclocarban (TCC), a formerly used disinfectant, kills bacteria via an unknown mechanism of action. A structural hallmark is its N,N′-diaryl urea motif, which is also present in other antibiotics, including the recently reported small molecule PK150. We show here that, like PK150, TCC exhibits an i...

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Bibliografische gegevens
Gepubliceerd in:Appl Environ Microbiol
Hoofdauteurs: Macsics, Robert, Hackl, Mathias W., Fetzer, Christian, Mostert, Dietrich, Bender, Jennifer, Layer, Franziska, Sieber, Stephan A.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society for Microbiology 2020
Onderwerpen:
Biotechnology
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7414967/
https://ncbi.nlm.nih.gov/pubmed/32503913
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AEM.00933-20
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