Disruption of super-enhancer-driven tumor suppressor gene RCAN1.4 expression promotes the malignancy of breast carcinoma

BACKGROUND: Super-enhancers (SEs) play a crucial role in cancer, which is often associate with activated oncogenes. However, little is known about how SEs facilitate tumour suppression. Individuals with Down syndrome exhibit a remarkably reduced incidence of breast cancer (BC), moving the search for...

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Gepubliceerd in:Mol Cancer
Hoofdauteurs: Deng, Rong, Huang, Jun-Hao, Wang, Yan, Zhou, Li-Huan, Wang, Zi-Feng, Hu, Bing-Xin, Chen, Yu-Hong, Yang, Dong, Mai, Jia, Li, Zhi-Ling, Zhang, Hai-Liang, Huang, Yun, Peng, Xiao-Dan, Feng, Gong-Kan, Zhu, Xiao-Feng, Tang, Jun
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: BioMed Central 2020
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Research
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7414732/
https://ncbi.nlm.nih.gov/pubmed/32771023
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12943-020-01236-z
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