Disruption of super-enhancer-driven tumor suppressor gene RCAN1.4 expression promotes the malignancy of breast carcinoma

Abstract Background Super-enhancers (SEs) play a crucial role in cancer, which is often associate with activated oncogenes. However, little is known about how SEs facilitate tumour suppression. Individuals with Down syndrome exhibit a remarkably reduced incidence of breast cancer (BC), moving the se...

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Bibliografski detalji
Glavni autori: Rong Deng, Jun-Hao Huang, Yan Wang, Li-Huan Zhou, Zi-Feng Wang, Bing-Xin Hu, Yu-Hong Chen, Dong Yang, Jia Mai, Zhi-Ling Li, Hai-Liang Zhang, Yun Huang, Xiao-Dan Peng, Gong-Kan Feng, Xiao-Feng Zhu, Jun Tang
Format: Artigo
Jezik:Inglês
Izdano: BMC 2020-08-01
Serija:Molecular Cancer
Teme:
Super-enhancer
RCAN1.4
RUNX3
BRD4
Breast carcinoma
Malignancy
Online pristup:http://link.springer.com/article/10.1186/s12943-020-01236-z
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