Hepatic transferrin plays a role in systemic iron homeostasis and liver ferroptosis

Although the serum-abundant metal-binding protein transferrin (encoded by the Trf gene) is synthesized primarily in the liver, its function in the liver is largely unknown. Here, we generated hepatocyte-specific Trf knockout mice (Trf-LKO), which are viable and fertile but have impaired erythropoies...

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Vydáno v:Blood
Hlavní autoři: Yu, Yingying, Jiang, Li, Wang, Hao, Shen, Zhe, Cheng, Qi, Zhang, Pan, Wang, Jiaming, Wu, Qian, Fang, Xuexian, Duan, Lingyan, Wang, Shufen, Wang, Kai, An, Peng, Shao, Tuo, Chung, Raymond T., Zheng, Shusen, Min, Junxia, Wang, Fudi
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society of Hematology 2020
Témata:
Red Cells, Iron, and Erythropoiesis
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7414596/
https://ncbi.nlm.nih.gov/pubmed/32374849
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood.2019002907
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