HNF4α regulates sulfur amino acid metabolism and confers sensitivity to methionine restriction in liver cancer

Methionine restriction, a dietary regimen that protects against metabolic diseases and aging, represses cancer growth and improves cancer therapy. However, the response of different cancer cells to this nutritional manipulation is highly variable, and the molecular determinants of this heterogeneity...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Xu, Qing, Li, Yuanyuan, Gao, Xia, Kang, Kai, Williams, Jason G., Tong, Lingfeng, Liu, Juan, Ji, Ming, Deterding, Leesa J., Tong, Xuemei, Locasale, Jason W., Li, Leping, Shats, Igor, Li, Xiaoling
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7414133/
https://ncbi.nlm.nih.gov/pubmed/32770044
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-17818-w
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