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Thermodynamic energetics underlying genomic instability and whole-genome doubling in cancer
Genomic instability contributes to tumorigenesis through the amplification and deletion of cancer driver genes. DNA copy number (CN) profiling of ensembles of tumors allows a thermodynamic analysis of the profile for each tumor. The free energy of the distribution of CNs is found to be a monotonical...
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| Publicat a: | Proc Natl Acad Sci U S A |
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| Autors principals: | , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
National Academy of Sciences
2020
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7414060/ https://ncbi.nlm.nih.gov/pubmed/32694208 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1920870117 |
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