Zinc-mediated conformational preselection mechanism in the allosteric control of DNA binding to the zinc transcriptional regulator (ZitR)

The zinc transcriptional regulator (ZitR) functions as a metalloregulator that fine tunes transcriptional regulation through zinc-dependent DNA binding. However, the molecular mechanism of zinc-driven allosteric control of the DNA binding to ZitR remains elusive. Here, we performed enhanced sampling...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Sci Rep
Prif Awduron: He, Xinheng, Ni, Duan, Zhang, Hao, Li, Xinyi, Zhang, Jian, Fu, Qiang, Liu, Yaqin, Lu, Shaoyong
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Nature Publishing Group UK 2020
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC7413533/
https://ncbi.nlm.nih.gov/pubmed/32764589
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-70381-8
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