Dynamic changes in the epigenomic landscape regulate human organogenesis and link to developmental disorders

How the genome activates or silences transcriptional programmes governs organ formation. Little is known in human embryos undermining our ability to benchmark the fidelity of stem cell differentiation or cell programming, or interpret the pathogenicity of noncoding variation. Here, we study histone...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Gerrard, Dave T., Berry, Andrew A., Jennings, Rachel E., Birket, Matthew J., Zarrineh, Peyman, Garstang, Myles G., Withey, Sarah L., Short, Patrick, Jiménez-Gancedo, Sandra, Firbas, Panos N., Donaldson, Ian, Sharrocks, Andrew D., Hanley, Karen Piper, Hurles, Matthew E., Gomez-Skarmeta, José Luis, Bobola, Nicoletta, Hanley, Neil A.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7413392/
https://ncbi.nlm.nih.gov/pubmed/32764605
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-17305-2
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