The REGγ inhibitor NIP30 increases sensitivity to chemotherapy in p53-deficient tumor cells

A major challenge in chemotherapy is chemotherapy resistance in cells lacking p53. Here we demonstrate that NIP30, an inhibitor of the oncogenic REGγ-proteasome, attenuates cancer cell growth and sensitizes p53-compromised cells to chemotherapeutic agents. NIP30 acts by binding to REGγ via an evolut...

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Vydáno v:Nat Commun
Hlavní autoři: Gao, Xiao, Wang, Qingwei, Wang, Ying, Liu, Jiang, Liu, Shuang, Liu, Jian, Zhou, Xingli, Zhou, Li, Chen, Hui, Pan, Linian, Chen, Jiwei, Wang, Da, Zhang, Qing, Shen, Shihui, Xiao, Yu, Wu, Zhipeng, Cheng, Yiyun, Chen, Geng, Krubra, Syeda, Qin, Jun, Huang, Lan, Zhang, Pei, Wang, Chuangui, Moses, Robb E., Lonard, David M., Malley, Bert W. O’, Fares, Fuad, Zhang, Bianhong, Li, Xiaotao, Li, Lei, Xiao, Jianru
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2020
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7413384/
https://ncbi.nlm.nih.gov/pubmed/32764536
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-17667-7
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