PD-L1 Is Expressed and Promotes the Expansion of Regulatory T Cells in Acute Myeloid Leukemia

Intratumoral accumulation of CD4(+)CD25(+)Foxp3(+) regulatory T (Treg) cells occurs in acute myeloid leukemia (AML), but little is known about the role of tumor cells themselves in this process. Here, we showed that an immune checkpoint PD-L1 expressed by AML cells promoted the conversion and expans...

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Detalhes bibliográficos
Publicado no:Front Immunol
Main Authors: Dong, Yuqing, Han, Yixiang, Huang, Yisha, Jiang, Songfu, Huang, Ziyang, Chen, Rongrong, Yu, Zhijie, Yu, Kang, Zhang, Shenghui
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2020
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7412746/
https://ncbi.nlm.nih.gov/pubmed/32849603
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2020.01710
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