Multi-Laboratory Comparison of Next-Generation to Sanger-Based Sequencing for HIV-1 Drug Resistance Genotyping

Next-generation sequencing (NGS) is increasingly used for HIV-1 drug resistance genotyping. NGS methods have the potential for a more sensitive detection of low-abundance variants (LAV) compared to standard Sanger sequencing (SS) methods. A standardized threshold for reporting LAV that generates dat...

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Udgivet i:Viruses
Main Authors: Parkin, Neil T., Avila-Rios, Santiago, Bibby, David F., Brumme, Chanson J., Eshleman, Susan H., Harrigan, P. Richard, Howison, Mark, Hunt, Gillian, Ji, Hezhao, Kantor, Rami, Ledwaba, Johanna, Lee, Emma R., Matías-Florentino, Margarita, Mbisa, Jean L., Noguera-Julian, Marc, Paredes, Roger, Rivera-Amill, Vanessa, Swanstrom, Ronald, Zaccaro, Daniel J., Zhang, Yinfeng, Zhou, Shuntai, Jennings, Cheryl
Format: Artigo
Sprog:Inglês
Udgivet: MDPI 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7411816/
https://ncbi.nlm.nih.gov/pubmed/32605062
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/v12070694
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