Multi-Laboratory Comparison of Next-Generation to Sanger-Based Sequencing for HIV-1 Drug Resistance Genotyping

Next-generation sequencing (NGS) is increasingly used for HIV-1 drug resistance genotyping. NGS methods have the potential for a more sensitive detection of low-abundance variants (LAV) compared to standard Sanger sequencing (SS) methods. A standardized threshold for reporting LAV that generates dat...

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Main Authors: Neil T. Parkin, Santiago Avila-Rios, David F. Bibby, Chanson J. Brumme, Susan H. Eshleman, P. Richard Harrigan, Mark Howison, Gillian Hunt, Hezhao Ji, Rami Kantor, Johanna Ledwaba, Emma R. Lee, Margarita Matías-Florentino, Jean L. Mbisa, Marc Noguera-Julian, Roger Paredes, Vanessa Rivera-Amill, Ronald Swanstrom, Daniel J. Zaccaro, Yinfeng Zhang, Shuntai Zhou, Cheryl Jennings
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI AG 2020-06-01
Colecção:Viruses
Assuntos:
HIV-1
drug resistance
genotyping
NGS
Acesso em linha:https://www.mdpi.com/1999-4915/12/7/694
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