Unraveling the mechanisms of chemotherapy-induced damage to human primordial follicle reserve: road to developing therapeutics for fertility preservation and reversing ovarian aging

Among the investigated mechanisms of chemotherapy-induced damage to human primordial follicle reserve are induction of DNA double-strand breaks (DSBs) and resultant apoptotic death, stromal–microvascular damage and follicle activation. Accumulating basic and translational evidence suggests that acut...

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Bibliografiske detaljer
Udgivet i:Mol Hum Reprod
Main Authors: Szymanska, Katarzyna J, Tan, Xiujuan, Oktay, Kutluk
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2020
Fag:
Review
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7411370/
https://ncbi.nlm.nih.gov/pubmed/32514568
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/molehr/gaaa043
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