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Immune phenotyping of diverse syngeneic murine brain tumors identifies immunologically distinct types

Immunotherapy has emerged as a promising approach to treat cancer, however, its efficacy in highly malignant brain-tumors, glioblastomas (GBM), is limited. Here, we generate distinct imageable syngeneic mouse GBM-tumor models and utilize RNA-sequencing, CyTOF and correlative immunohistochemistry to...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Khalsa, Jasneet Kaur, Cheng, Nina, Keegan, Joshua, Chaudry, Ameen, Driver, Joseph, Bi, Wenya Linda, Lederer, James, Shah, Khalid
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7411074/
https://ncbi.nlm.nih.gov/pubmed/32764562
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-17704-5
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