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Chronic administration of the N-methyl-D-aspartate receptor antagonist ketamine improves Rett syndrome phenotype

BACKGROUND: Rett syndrome (RTT) is a neurological disorder caused by mutation of the X-linked MECP2 gene, which results in the progressive disruption of excitatory and inhibitory neuronal circuits. To date, there is no effective treatment available for the disorder. Studies conducted in RTT patients...

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Detalhes bibliográficos
Publicado no:Biol Psychiatry
Main Authors: Patrizi, Annarita, Picard, Nathalie, Simon, Alex Joseph, Gunner, Georgia, Centofante, Eleonora, Andrews, Nick Arthur, Fagiolini, Michela
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7410367/
https://ncbi.nlm.nih.gov/pubmed/26410354
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.biopsych.2015.08.018
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