Complement factor H–deficient mice develop spontaneous hepatic tumors

Hepatocellular carcinoma (HCC) is difficult to detect, carries a poor prognosis, and is one of few cancers with an increasing yearly incidence. Molecular defects in complement factor H (CFH), a critical regulatory protein of the complement alternative pathway (AP), are typically associated with infl...

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Vydáno v:J Clin Invest
Hlavní autoři: Laskowski, Jennifer, Renner, Brandon, Pickering, Matthew C., Serkova, Natalie J., Smith-Jones, Peter M., Clambey, Eric T., Nemenoff, Raphael A., Thurman, Joshua M.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Clinical Investigation 2020
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7410061/
https://ncbi.nlm.nih.gov/pubmed/32369457
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI135105
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