Autoantibodies targeting TRIM72 compromise membrane repair and contribute to inflammatory myopathy

Idiopathic inflammatory myopathies (IIM) involve chronic inflammation of skeletal muscle and subsequent muscle degeneration due to an uncontrolled autoimmune response; however, the mechanisms leading to pathogenesis are not well understood. A compromised sarcolemmal repair process could promote an a...

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Detalhes bibliográficos
Publicado no:J Clin Invest
Main Authors: McElhanon, Kevin E., Young, Nicholas, Hampton, Jeffrey, Paleo, Brian J., Kwiatkowski, Thomas A., Beck, Eric X, Capati, Ana, Jablonski, Kyle, Gurney, Travis, Perez, Miguel A. Lopez, Aggarwal, Rohit, Oddis, Chester V., Jarjour, Wael N., Weisleder, Noah
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2020
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7410050/
https://ncbi.nlm.nih.gov/pubmed/32687067
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI131721
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