Targeting the innate immunoreceptor RIG-I overcomes melanoma-intrinsic resistance to T cell immunotherapy

Understanding tumor resistance to T cell immunotherapies is critical to improve patient outcomes. Our study revealed a role for transcriptional suppression of the tumor-intrinsic HLA class I (HLA-I) antigen processing and presentation machinery (APM) in therapy resistance. Low HLA-I APM mRNA levels...

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Bibliografische gegevens
Gepubliceerd in:J Clin Invest
Hoofdauteurs: Such, Lina, Zhao, Fang, Liu, Derek, Thier, Beatrice, Le-Trilling, Vu Thuy Khanh, Sucker, Antje, Coch, Christoph, Pieper, Natalia, Howe, Sebastian, Bhat, Hilal, Kalkavan, Halime, Ritter, Cathrin, Brinkhaus, Robin, Ugurel, Selma, Köster, Johannes, Seifert, Ulrike, Dittmer, Ulf, Schuler, Martin, Lang, Karl S., Kufer, Thomas A., Hartmann, Gunther, Becker, Jürgen C., Horn, Susanne, Ferrone, Soldano, Liu, David, Van Allen, Eliezer M., Schadendorf, Dirk, Griewank, Klaus, Trilling, Mirko, Paschen, Annette
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society for Clinical Investigation 2020
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Research Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7410049/
https://ncbi.nlm.nih.gov/pubmed/32427578
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI131572
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