Targeting the innate immunoreceptor RIG-I overcomes melanoma-intrinsic resistance to T cell immunotherapy

Understanding tumor resistance to T cell immunotherapies is critical to improve patient outcomes. Our study revealed a role for transcriptional suppression of the tumor-intrinsic HLA class I (HLA-I) antigen processing and presentation machinery (APM) in therapy resistance. Low HLA-I APM mRNA levels...

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Detalhes bibliográficos
Publicado no:J Clin Invest
Main Authors: Such, Lina, Zhao, Fang, Liu, Derek, Thier, Beatrice, Le-Trilling, Vu Thuy Khanh, Sucker, Antje, Coch, Christoph, Pieper, Natalia, Howe, Sebastian, Bhat, Hilal, Kalkavan, Halime, Ritter, Cathrin, Brinkhaus, Robin, Ugurel, Selma, Köster, Johannes, Seifert, Ulrike, Dittmer, Ulf, Schuler, Martin, Lang, Karl S., Kufer, Thomas A., Hartmann, Gunther, Becker, Jürgen C., Horn, Susanne, Ferrone, Soldano, Liu, David, Van Allen, Eliezer M., Schadendorf, Dirk, Griewank, Klaus, Trilling, Mirko, Paschen, Annette
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2020
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7410049/
https://ncbi.nlm.nih.gov/pubmed/32427578
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI131572
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