Genome-wide R-loop analysis defines unique roles for DDX5, XRN2, and PRMT5 in DNA/RNA hybrid resolution

DDX5, XRN2, and PRMT5 have been shown to resolve DNA/RNA hybrids (R-loops) at RNA polymerase II transcription termination sites at few genomic loci. Herein, we perform genome-wide R-loop mapping using classical DNA/RNA immunoprecipitation and high-throughput sequencing (DRIP-seq) of loci regulated b...

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Publicado en:Life Sci Alliance
Main Authors: Villarreal, Oscar D, Mersaoui, Sofiane Y, Yu, Zhenbao, Masson, Jean-Yves, Richard, Stéphane
Formato: Artigo
Idioma:Inglês
Publicado: Life Science Alliance LLC 2020
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7409538/
https://ncbi.nlm.nih.gov/pubmed/32747416
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.26508/lsa.202000762
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