CN133, a Novel Brain-Penetrating Histone Deacetylase Inhibitor, Hampers Tumor Growth in Patient-Derived Pediatric Posterior Fossa Ependymoma Models

Pediatric ependymoma (EPN) is a highly aggressive tumor of the central nervous system that remains incurable in 40% of cases. In children, the majority of cases develop in the posterior fossa and can be classified into two distinct molecular entities: EPN posterior fossa A (PF-EPN-A) and EPN posteri...

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Veröffentlicht in:Cancers (Basel)
Hauptverfasser: Antonelli, Roberta, Jiménez, Carlos, Riley, Misha, Servidei, Tiziana, Riccardi, Riccardo, Soriano, Aroa, Roma, Josep, Martínez-Saez, Elena, Martini, Maurizio, Ruggiero, Antonio, Moreno, Lucas, Sánchez de Toledo, Josep, Gallego, Soledad, Bové, Jordi, Hooker, Jacob M., Segura, Miguel F.
Format: Artigo
Sprache:Inglês
Veröffentlicht: MDPI 2020
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7409080/
https://ncbi.nlm.nih.gov/pubmed/32708733
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cancers12071922
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