Hepatic protein-tyrosine phosphatase 1B disruption and pharmacological inhibition attenuate ethanol-induced oxidative stress and ameliorate alcoholic liver disease in mice

Alcoholic liver disease (ALD) is a major health problem and a significant cause of liver-related death. Currently, the mainstay for ALD therapy is alcohol abstinence highlighting the need to develop pharmacotherapeutic approaches. Protein-tyrosine phosphatase 1B (PTP1B) is an established regulator o...

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Gepubliceerd in:Redox Biol
Hoofdauteurs: Hsu, Ming-Fo, Koike, Shinichiro, Mello, Aline, Nagy, Laura E., Haj, Fawaz G.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Elsevier 2020
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Research Paper
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7408361/
https://ncbi.nlm.nih.gov/pubmed/32769011
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.redox.2020.101658
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