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An Oncogenic Hepatocyte-Induced Orthotopic Mouse Model of Hepatocellular Cancer Arising in the Setting of Hepatic Inflammation and Fibrosis

The absence of a clinically relevant animal model addressing the typical immune characteristics of hepatocellular cancer (HCC) has significantly impeded elucidation of the underlying mechanisms and development of innovative immunotherapeutic strategies. To develop an ideal animal model recapitulatin...

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Détails bibliographiques
Publié dans:J Vis Exp
Auteurs principaux: Qi, Xiaoqiang, Schepers, Emily, Avella, Diego, Kimchi, Eric T., Kaifi, Jussuf T., Staveley-O’Carroll, Kevin F., Li, Guangfu
Format: Artigo
Langue:Inglês
Publié: 2019
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7408290/
https://ncbi.nlm.nih.gov/pubmed/31566616
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3791/59368
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