TRPV4 Inhibition and CRISPR-Cas9 Knockout Reduce Inflammation Induced by Hyperphysiological Stretching in Human Annulus Fibrosus Cells

Mechanical loading and inflammation interact to cause degenerative disc disease and low back pain (LBP). However, the underlying mechanosensing and mechanotransductive pathways are poorly understood. This results in untargeted pharmacological treatments that do not take the mechanical aspect of LBP...

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Bibliografski detalji
Izdano u:Cells
Glavni autori: Cambria, Elena, Arlt, Matthias J. E., Wandel, Sandra, Krupkova, Olga, Hitzl, Wolfgang, Passini, Fabian S., Hausmann, Oliver N., Snedeker, Jess G., Ferguson, Stephen J., Wuertz-Kozak, Karin
Format: Artigo
Jezik:Inglês
Izdano: MDPI 2020
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Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7407144/
https://ncbi.nlm.nih.gov/pubmed/32708074
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cells9071736
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