TRPV4 Inhibition and CRISPR-Cas9 Knockout Reduce Inflammation Induced by Hyperphysiological Stretching in Human Annulus Fibrosus Cells

Mechanical loading and inflammation interact to cause degenerative disc disease and low back pain (LBP). However, the underlying mechanosensing and mechanotransductive pathways are poorly understood. This results in untargeted pharmacological treatments that do not take the mechanical aspect of LBP...

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Publicat a:Cells
Autors principals: Cambria, Elena, Arlt, Matthias J. E., Wandel, Sandra, Krupkova, Olga, Hitzl, Wolfgang, Passini, Fabian S., Hausmann, Oliver N., Snedeker, Jess G., Ferguson, Stephen J., Wuertz-Kozak, Karin
Format: Artigo
Idioma:Inglês
Publicat: MDPI 2020
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7407144/
https://ncbi.nlm.nih.gov/pubmed/32708074
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cells9071736
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