MTH1 favors mesothelioma progression and mediates paracrine rescue of bystander endothelium from oxidative damage

Oxidative stress and inadequate redox homeostasis is crucial for tumor initiation and progression. MTH1 (NUDT1) enzyme prevents incorporation of oxidized dNTPs by sanitizing the deoxynucleoside triphosphate (dNTP) pool and is therefore vital for the survival of tumor cells. MTH1 inhibition has been...

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Publicado en:JCI Insight
Main Authors: Magkouta, Sophia F., Pappas, Apostolos G., Vaitsi, Photene C., Agioutantis, Panagiotis C., Pateras, Ioannis S., Moschos, Charalampos A., Iliopoulou, Marianthi P., Kosti, Chrysavgi N., Loutrari, Heleni V., Gorgoulis, Vassilis G., Kalomenidis, Ioannis T.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Clinical Investigation 2020
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7406306/
https://ncbi.nlm.nih.gov/pubmed/32554927
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.134885
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