MTH1 favors mesothelioma progression and mediates paracrine rescue of bystander endothelium from oxidative damage

Oxidative stress and inadequate redox homeostasis is crucial for tumor initiation and progression. MTH1 (NUDT1) enzyme prevents incorporation of oxidized dNTPs by sanitizing the deoxynucleoside triphosphate (dNTP) pool and is therefore vital for the survival of tumor cells. MTH1 inhibition has been...

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Vydáno v:JCI Insight
Hlavní autoři: Magkouta, Sophia F., Pappas, Apostolos G., Vaitsi, Photene C., Agioutantis, Panagiotis C., Pateras, Ioannis S., Moschos, Charalampos A., Iliopoulou, Marianthi P., Kosti, Chrysavgi N., Loutrari, Heleni V., Gorgoulis, Vassilis G., Kalomenidis, Ioannis T.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Clinical Investigation 2020
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7406306/
https://ncbi.nlm.nih.gov/pubmed/32554927
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.134885
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