Longitudinal analysis of naturally acquired PfEMP1 CIDR domain variant antibodies identifies associations with malaria protection

BACKGROUND: Malaria pathogenicity is determined, in part, by the adherence of Plasmodium falciparum–infected erythrocytes to the microvasculature mediated via specific interactions between P. falciparum erythrocyte membrane protein (PfEMP1) variant domains and host endothelial receptors. Naturally a...

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Vydáno v:JCI Insight
Hlavní autoři: Obeng-Adjei, Nyamekye, Larremore, Daniel B., Turner, Louise, Ongoiba, Aissata, Li, Shanping, Doumbo, Safiatou, Yazew, Takele B., Kayentao, Kassoum, Miller, Louis H., Traore, Boubacar, Pierce, Susan K., Buckee, Caroline O., Lavstsen, Thomas, Crompton, Peter D., Tran, Tuan M.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Clinical Investigation 2020
Témata:
Clinical Medicine
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7406271/
https://ncbi.nlm.nih.gov/pubmed/32427581
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.137262
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