RAGE impairs murine diabetic atherosclerosis regression and implicates IRF7 in macrophage inflammation and cholesterol metabolism

Despite advances in lipid-lowering therapies, people with diabetes continue to experience more limited cardiovascular benefits. In diabetes, hyperglycemia sustains inflammation and preempts vascular repair. We tested the hypothesis that the receptor for advanced glycation end-products (RAGE) contrib...

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Vydáno v:JCI Insight
Hlavní autoři: Senatus, Laura, López-Díez, Raquel, Egaña-Gorroño, Lander, Liu, Jianhua, Hu, Jiyuan, Daffu, Gurdip, Li, Qing, Rahman, Karishma, Vengrenyuk, Yuliya, Barrett, Tessa J., Dewan, M. Zahidunnabi, Guo, Liang, Fuller, Daniela, Finn, Aloke V., Virmani, Renu, Li, Huilin, Friedman, Richard A., Fisher, Edward A., Ramasamy, Ravichandran, Schmidt, Ann Marie
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Clinical Investigation 2020
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7406264/
https://ncbi.nlm.nih.gov/pubmed/32641587
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.137289
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