RAGE impairs murine diabetic atherosclerosis regression and implicates IRF7 in macrophage inflammation and cholesterol metabolism

Despite advances in lipid-lowering therapies, people with diabetes continue to experience more limited cardiovascular benefits. In diabetes, hyperglycemia sustains inflammation and preempts vascular repair. We tested the hypothesis that the receptor for advanced glycation end-products (RAGE) contrib...

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Detalhes bibliográficos
Publicado no:JCI Insight
Main Authors: Senatus, Laura, López-Díez, Raquel, Egaña-Gorroño, Lander, Liu, Jianhua, Hu, Jiyuan, Daffu, Gurdip, Li, Qing, Rahman, Karishma, Vengrenyuk, Yuliya, Barrett, Tessa J., Dewan, M. Zahidunnabi, Guo, Liang, Fuller, Daniela, Finn, Aloke V., Virmani, Renu, Li, Huilin, Friedman, Richard A., Fisher, Edward A., Ramasamy, Ravichandran, Schmidt, Ann Marie
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2020
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7406264/
https://ncbi.nlm.nih.gov/pubmed/32641587
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.137289
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