Differential effects of PD-L1 versus PD-1 blockade on myeloid inflammation in human cancer

BACKGROUND: PD-1 and PD-L1 have been studied interchangeably in the clinic as checkpoints to reinvigorate T cells in diverse tumor types. Data for biologic effects of checkpoint blockade in human premalignancy are limited. METHODS: We analyzed the immunologic effects of PD-L1 blockade in a clinical...

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Foilsithe in:JCI Insight
Main Authors: Bar, Noffar, Costa, Federica, Das, Rituparna, Duffy, Alyssa, Samur, Mehmet, McCachren, Samuel, Gettinger, Scott N., Neparidze, Natalia, Parker, Terri L., Bailur, Jithendra Kini, Pendleton, Katherine, Bajpai, Richa, Zhang, Lin, Xu, Mina L., Anderson, Tara, Giuliani, Nicola, Nooka, Ajay, Cho, Hearn J., Raval, Aparna, Shanmugam, Mala, Dhodapkar, Kavita M., Dhodapkar, Madhav V.
Formáid: Artigo
Teanga:Inglês
Foilsithe: American Society for Clinical Investigation 2020
Ábhair:
Clinical Medicine
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7406262/
https://ncbi.nlm.nih.gov/pubmed/32427579
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.129353
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