Differential effects of PD-L1 versus PD-1 blockade on myeloid inflammation in human cancer

BACKGROUND: PD-1 and PD-L1 have been studied interchangeably in the clinic as checkpoints to reinvigorate T cells in diverse tumor types. Data for biologic effects of checkpoint blockade in human premalignancy are limited. METHODS: We analyzed the immunologic effects of PD-L1 blockade in a clinical...

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Bibliografische gegevens
Gepubliceerd in:JCI Insight
Hoofdauteurs: Bar, Noffar, Costa, Federica, Das, Rituparna, Duffy, Alyssa, Samur, Mehmet, McCachren, Samuel, Gettinger, Scott N., Neparidze, Natalia, Parker, Terri L., Bailur, Jithendra Kini, Pendleton, Katherine, Bajpai, Richa, Zhang, Lin, Xu, Mina L., Anderson, Tara, Giuliani, Nicola, Nooka, Ajay, Cho, Hearn J., Raval, Aparna, Shanmugam, Mala, Dhodapkar, Kavita M., Dhodapkar, Madhav V.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society for Clinical Investigation 2020
Onderwerpen:
Clinical Medicine
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7406262/
https://ncbi.nlm.nih.gov/pubmed/32427579
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.129353
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