Differential effects of PD-L1 versus PD-1 blockade on myeloid inflammation in human cancer

BACKGROUND: PD-1 and PD-L1 have been studied interchangeably in the clinic as checkpoints to reinvigorate T cells in diverse tumor types. Data for biologic effects of checkpoint blockade in human premalignancy are limited. METHODS: We analyzed the immunologic effects of PD-L1 blockade in a clinical...

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Publicat a:JCI Insight
Autors principals: Bar, Noffar, Costa, Federica, Das, Rituparna, Duffy, Alyssa, Samur, Mehmet, McCachren, Samuel, Gettinger, Scott N., Neparidze, Natalia, Parker, Terri L., Bailur, Jithendra Kini, Pendleton, Katherine, Bajpai, Richa, Zhang, Lin, Xu, Mina L., Anderson, Tara, Giuliani, Nicola, Nooka, Ajay, Cho, Hearn J., Raval, Aparna, Shanmugam, Mala, Dhodapkar, Kavita M., Dhodapkar, Madhav V.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Clinical Investigation 2020
Matèries:
Clinical Medicine
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7406262/
https://ncbi.nlm.nih.gov/pubmed/32427579
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.129353
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