Differential effects of PD-L1 versus PD-1 blockade on myeloid inflammation in human cancer

BACKGROUND: PD-1 and PD-L1 have been studied interchangeably in the clinic as checkpoints to reinvigorate T cells in diverse tumor types. Data for biologic effects of checkpoint blockade in human premalignancy are limited. METHODS: We analyzed the immunologic effects of PD-L1 blockade in a clinical...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:JCI Insight
Prif Awduron: Bar, Noffar, Costa, Federica, Das, Rituparna, Duffy, Alyssa, Samur, Mehmet, McCachren, Samuel, Gettinger, Scott N., Neparidze, Natalia, Parker, Terri L., Bailur, Jithendra Kini, Pendleton, Katherine, Bajpai, Richa, Zhang, Lin, Xu, Mina L., Anderson, Tara, Giuliani, Nicola, Nooka, Ajay, Cho, Hearn J., Raval, Aparna, Shanmugam, Mala, Dhodapkar, Kavita M., Dhodapkar, Madhav V.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Society for Clinical Investigation 2020
Pynciau:
Clinical Medicine
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC7406262/
https://ncbi.nlm.nih.gov/pubmed/32427579
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.129353
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