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TrkB agonists prevent postischemic emergence of refractory neonatal seizures in mice
Refractory neonatal seizures do not respond to first-line antiseizure medications like phenobarbital (PB), a positive allosteric modulator for GABA(A) receptors. GABA(A) receptor–mediated inhibition is dependent upon electroneutral cation-chloride transporter KCC2, which mediates neuronal chloride e...
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| Publicado no: | JCI Insight |
|---|---|
| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Clinical Investigation
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7406252/ https://ncbi.nlm.nih.gov/pubmed/32427585 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.136007 |
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