The senescence-associated secretome as an indicator of age and medical risk

Produced by senescent cells, the senescence-associated secretory phenotype (SASP) is a potential driver of age-related dysfunction. We tested whether circulating concentrations of SASP proteins reflect age and medical risk in humans. We first screened senescent endothelial cells, fibroblasts, preadi...

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Bibliografske podrobnosti
izdano v:JCI Insight
Main Authors: Schafer, Marissa J., Zhang, Xu, Kumar, Amanika, Atkinson, Elizabeth J., Zhu, Yi, Jachim, Sarah, Mazula, Daniel L., Brown, Ashley K., Berning, Michelle, Aversa, Zaira, Kotajarvi, Brian, Bruce, Charles J., Greason, Kevin L., Suri, Rakesh M., Tracy, Russell P., Cummings, Steven R., White, Thomas A., LeBrasseur, Nathan K.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Clinical Investigation 2020
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7406245/
https://ncbi.nlm.nih.gov/pubmed/32554926
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.133668
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