The senescence-associated secretome as an indicator of age and medical risk

Produced by senescent cells, the senescence-associated secretory phenotype (SASP) is a potential driver of age-related dysfunction. We tested whether circulating concentrations of SASP proteins reflect age and medical risk in humans. We first screened senescent endothelial cells, fibroblasts, preadi...

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Publicado en:JCI Insight
Main Authors: Schafer, Marissa J., Zhang, Xu, Kumar, Amanika, Atkinson, Elizabeth J., Zhu, Yi, Jachim, Sarah, Mazula, Daniel L., Brown, Ashley K., Berning, Michelle, Aversa, Zaira, Kotajarvi, Brian, Bruce, Charles J., Greason, Kevin L., Suri, Rakesh M., Tracy, Russell P., Cummings, Steven R., White, Thomas A., LeBrasseur, Nathan K.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Clinical Investigation 2020
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7406245/
https://ncbi.nlm.nih.gov/pubmed/32554926
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.133668
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