The senescence-associated secretome as an indicator of age and medical risk

Produced by senescent cells, the senescence-associated secretory phenotype (SASP) is a potential driver of age-related dysfunction. We tested whether circulating concentrations of SASP proteins reflect age and medical risk in humans. We first screened senescent endothelial cells, fibroblasts, preadi...

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Detalhes bibliográficos
Publicado no:JCI Insight
Main Authors: Schafer, Marissa J., Zhang, Xu, Kumar, Amanika, Atkinson, Elizabeth J., Zhu, Yi, Jachim, Sarah, Mazula, Daniel L., Brown, Ashley K., Berning, Michelle, Aversa, Zaira, Kotajarvi, Brian, Bruce, Charles J., Greason, Kevin L., Suri, Rakesh M., Tracy, Russell P., Cummings, Steven R., White, Thomas A., LeBrasseur, Nathan K.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2020
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7406245/
https://ncbi.nlm.nih.gov/pubmed/32554926
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.133668
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