The senescence-associated secretome as an indicator of age and medical risk

Produced by senescent cells, the senescence-associated secretory phenotype (SASP) is a potential driver of age-related dysfunction. We tested whether circulating concentrations of SASP proteins reflect age and medical risk in humans. We first screened senescent endothelial cells, fibroblasts, preadi...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:JCI Insight
Prif Awduron: Schafer, Marissa J., Zhang, Xu, Kumar, Amanika, Atkinson, Elizabeth J., Zhu, Yi, Jachim, Sarah, Mazula, Daniel L., Brown, Ashley K., Berning, Michelle, Aversa, Zaira, Kotajarvi, Brian, Bruce, Charles J., Greason, Kevin L., Suri, Rakesh M., Tracy, Russell P., Cummings, Steven R., White, Thomas A., LeBrasseur, Nathan K.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Society for Clinical Investigation 2020
Pynciau:
Research Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC7406245/
https://ncbi.nlm.nih.gov/pubmed/32554926
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.133668
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