Protein-based, but not viral vector alone, HIV vaccine boosting drives an IgG1-biased polyfunctional humoral immune response

The RV144 HIV-1 vaccine trial results showed moderate reduction in viral infections among vaccinees as well as induction of antibody-dependent cellular cytotoxicity and vaccine-specific IgG and IgG3 responses directed at variable loop regions 1 and 2 of the HIV envelope protein. However, with the re...

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Vydáno v:JCI Insight
Hlavní autoři: Fischinger, Stephanie, Shin, Sally, Boudreau, Carolyn M., Ackerman, Margaret, Rerks-Ngarm, Supachai, Pitisuttithum, Punnee, Nitayaphan, Sorachai, Kim, Jerome H., Robb, Merlin L., Michael, Nelson L., O’Connell, Robert J., Vasan, Sandhya, Streeck, Hendrik, Alter, Galit
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Clinical Investigation 2020
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7406243/
https://ncbi.nlm.nih.gov/pubmed/32554928
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.135057
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