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Factor VIIa induces biased cytoprotective signal in mice through the cleavage of PAR1 at canonical Arg41 site
OBJECTIVE: Recent studies showed that factor VIIa (FVIIa), upon binding to endothelial cell protein C receptor, elicits endothelial barrier stabilization and anti-inflammatory effects via activation of protease-activated receptor 1 (PAR1)- mediated signaling. It is unknown whether FVIIa induces PAR1...
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| Pubblicato in: | Arterioscler Thromb Vasc Biol |
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| Autori principali: | , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2020
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7405933/ https://ncbi.nlm.nih.gov/pubmed/32212848 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/ATVBAHA.120.314244 |
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