Electrophysiological Alterations of Pyramidal Cells and Interneurons of the CA1 Region of the Hippocampus in a Novel Mouse Model of Dravet Syndrome

Dravet syndrome is a developmental epileptic encephalopathy caused by pathogenic variation in SCN1A. To characterize the pathogenic substitution (p.H939R) of a local individual with Dravet syndrome, fibroblast cells from the individual were reprogrammed to pluripotent stem cells and differentiated i...

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Bibliographic Details
Published in:Genetics
Main Authors: Dyment, David A., Schock, Sarah C., Deloughery, Kristen, Tran, Minh Hieu, Ure, Kerstin, Nutter, Lauryl M. J., Creighton, Amie, Yuan, Julie, Banderali, Umberto, Comas, Tanya, Baumann, Ewa, Jezierski, Anna, Boycott, Kym M., Mackenzie, Alex E., Martina, Marzia
Format: Artigo
Language:Inglês
Published: Genetics Society of America 2020
Subjects:
Investigations
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7404236/
https://ncbi.nlm.nih.gov/pubmed/32554600
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1534/genetics.120.303399
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