Electrophysiological Alterations of Pyramidal Cells and Interneurons of the CA1 Region of the Hippocampus in a Novel Mouse Model of Dravet Syndrome

Dravet syndrome is a developmental epileptic encephalopathy caused by pathogenic variation in SCN1A. To characterize the pathogenic substitution (p.H939R) of a local individual with Dravet syndrome, fibroblast cells from the individual were reprogrammed to pluripotent stem cells and differentiated i...

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Detalhes bibliográficos
Publicado no:Genetics
Main Authors: Dyment, David A., Schock, Sarah C., Deloughery, Kristen, Tran, Minh Hieu, Ure, Kerstin, Nutter, Lauryl M. J., Creighton, Amie, Yuan, Julie, Banderali, Umberto, Comas, Tanya, Baumann, Ewa, Jezierski, Anna, Boycott, Kym M., Mackenzie, Alex E., Martina, Marzia
Formato: Artigo
Idioma:Inglês
Publicado em: Genetics Society of America 2020
Assuntos:
Investigations
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7404236/
https://ncbi.nlm.nih.gov/pubmed/32554600
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1534/genetics.120.303399
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