Anti-CXCL4 Antibody Reactivity Is Present in Systemic Sclerosis (SSc) and Correlates with the SSc Type I Interferon Signature

Systemic sclerosis (SSc) is characterized by skin/internal organ fibrosis, vasculopathy and autoimmunity. Chemokine (C-X-C motif) ligand 4 (CXCL4) is an SSc biomarker, predicting unfavorable prognosis and lung fibrosis. CXCL4 binds DNA/RNA and favors interferon (IFN)-α production by plasmacytoid den...

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Publié dans:Int J Mol Sci
Auteurs principaux: Lande, Roberto, Mennella, Anna, Palazzo, Raffaella, Pietraforte, Immacolata, Stefanantoni, Katia, Iannace, Nicoletta, Butera, Alessia, Boirivant, Monica, Pica, Roberta, Conrad, Curdin, Chizzolini, Carlo, Riccieri, Valeria, Frasca, Loredana
Format: Artigo
Langue:Inglês
Publié: MDPI 2020
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7404208/
https://ncbi.nlm.nih.gov/pubmed/32707718
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms21145102
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