Loss of Dystroglycan Drives Cellular Senescence via Defective Mitosis-Mediated Genomic Instability

Nuclear β-dystroglycan (β-DG) is involved in the maintenance of nuclear architecture and function. Nonetheless, its relevance in defined nuclear processes remains to be determined. In this study we generated a C2C12 cell-based DG-null model using CRISPR-Cas9 technology to provide insights into the r...

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Vydáno v:Int J Mol Sci
Hlavní autoři: Jimenez-Gutierrez, Guadalupe Elizabeth, Mondragon-Gonzalez, Ricardo, Soto-Ponce, Luz Adriana, Gómez-Monsiváis, Wendy Lilián, García-Aguirre, Ian, Pacheco-Rivera, Ruth Abigail, Suárez-Sánchez, Rocío, Brancaccio, Andrea, Magaña, Jonathan Javier, C.R. Perlingeiro, Rita, Cisneros, Bulmaro
Médium: Artigo
Jazyk:Inglês
Vydáno: MDPI 2020
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7404207/
https://ncbi.nlm.nih.gov/pubmed/32674290
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms21144961
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