Imidazo[1,2-b]pyrazole-7-Carboxamide Derivative Induces Differentiation-Coupled Apoptosis of Immature Myeloid Cells Such as Acute Myeloid Leukemia and Myeloid-Derived Suppressor Cells

Chemotherapy-induced differentiation of immature myeloid progenitors, such as acute myeloid leukemia (AML) cells or myeloid-derived suppressor cells (MDSCs), has remained a challenge for the clinicians. Testing our imidazo[1,2-b]pyrazole-7-carboxamide derivative on HL-60 cells, we obtained ERK phosp...

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Publicado en:Int J Mol Sci
Autores principales: Kotogány, Edit, Balog, József Á., Nagy, Lajos I., Alföldi, Róbert, Bertagnolo, Valeria, Brugnoli, Federica, Demjén, András, Kovács, Anita K., Batár, Péter, Mezei, Gabriella, Szabó, Renáta, Kanizsai, Iván, Varga, Csaba, Puskás, László G., Szebeni, Gábor J.
Formato: Artigo
Lenguaje:Inglês
Publicado: MDPI 2020
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7404197/
https://ncbi.nlm.nih.gov/pubmed/32698503
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms21145135
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