Proteomics Reveals that Methylmalonyl-CoA Mutase Modulates Cell Architecture and Increases Susceptibility to Stress

Methylmalonic acidemia (MMA) is a rare inborn error of metabolism caused by deficiency of the methylmalonyl-CoA mutase (MUT) enzyme. Downstream MUT deficiency, methylmalonic acid accumulates together with toxic metabolites from propionyl-CoA and other compounds upstream of the block in the enzyme pa...

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Bibliographic Details
Published in:Int J Mol Sci
Main Authors: Costanzo, Michele, Caterino, Marianna, Cevenini, Armando, Jung, Vincent, Chhuon, Cerina, Lipecka, Joanna, Fedele, Roberta, Guerrera, Ida Chiara, Ruoppolo, Margherita
Format: Artigo
Language:Inglês
Published: MDPI 2020
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7403994/
https://ncbi.nlm.nih.gov/pubmed/32679819
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms21144998
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