Mebendazole is unique among tubulin-active drugs in activating the MEK–ERK pathway

We recently showed that the anti-helminthic compound mebendazole (MBZ) has immunomodulating activity in monocyte/macrophage models and induces ERK signalling. In the present study we investigated whether MBZ induced ERK activation is shared by other tubulin binding agents (TBAs) and if it is observa...

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Published in:Sci Rep
Main Authors: Andersson, Claes R., Selvin, Tove, Blom, Kristin, Rubin, Jenny, Berglund, Malin, Jarvius, Malin, Lenhammar, Lena, Parrow, Vendela, Loskog, Angelica, Fryknäs, Mårten, Nygren, Peter, Larsson, Rolf
Format: Artigo
Language:Inglês
Published: Nature Publishing Group UK 2020
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7403428/
https://ncbi.nlm.nih.gov/pubmed/32753665
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-68986-0
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