Mebendazole-induced M1 polarisation of THP-1 macrophages may involve DYRK1B inhibition

OBJECTIVE: We recently showed that the anti-helminthic compound mebendazole (MBZ) has immunomodulating activity by inducing a M2 to M1 phenotype switch in monocyte/macrophage models. In the present study we investigated the potential role of protein kinases in mediating this effect. RESULTS: MBZ pot...

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Veröffentlicht in:BMC Res Notes
Hauptverfasser: Blom, Kristin, Rubin, Jenny, Berglund, Malin, Jarvius, Malin, Lenhammar, Lena, Parrow, Vendela, Andersson, Claes, Loskog, Angelica, Fryknäs, Mårten, Nygren, Peter, Larsson, Rolf
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2019
Schlagworte:
Research Note
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6477744/
https://ncbi.nlm.nih.gov/pubmed/31010428
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13104-019-4273-5
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