CDK4/6 inhibition presents as a therapeutic option for paediatric and adult germ cell tumours and induces cell cycle arrest and apoptosis via canonical and non-canonical mechanisms

BACKGROUND: Germ cell tumours (GCTs) are the most common solid malignancies in young men. Although high cure rates can be achieved, metastases, resistance to cisplatin-based therapy and late toxicities still represent a lethal threat, arguing for the need of new therapeutic options. In this study, w...

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Опубликовано в: :Br J Cancer
Главные авторы: Skowron, Margaretha A., Vermeulen, Marieke, Winkelhausen, Anna, Becker, Teresa K., Bremmer, Felix, Petzsch, Patrick, Schönberger, Stefan, Calaminus, Gabriele, Köhrer, Karl, Albers, Peter, Nettersheim, Daniel
Формат: Artigo
Язык:Inglês
Опубликовано: Nature Publishing Group UK 2020
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC7403155/
https://ncbi.nlm.nih.gov/pubmed/32418994
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41416-020-0891-x
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