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A novel function of R-spondin1 in regulating estrogen receptor expression independent of Wnt/β-catenin signaling
R-spondin1 (Rspo1) has been featured as a Wnt agonist, serving as a potent niche factor for stem cells in many tissues. Here we unveil a novel role of Rspo1 in promoting estrogen receptor alpha (Esr1) expression, hence regulating the output of steroid hormone signaling in the mouse mammary gland. Th...
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| Publicado no: | eLife |
|---|---|
| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
eLife Sciences Publications, Ltd
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7402675/ https://ncbi.nlm.nih.gov/pubmed/32749219 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.56434 |
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