64. AN ENT2-DEPENDENT, CELL-PENETRATING, AND DNA-DAMAGING LUPUS AUTOANTIBODY CROSSES THE BLOOD-BRAIN BARRIER TO TARGET BRAIN TUMORS

The blood-brain barrier (BBB) limits conventional antibody-based approaches to brain tumors. ENT2, an equilibrative nucleoside transporter, facilitates penetration of autoantibodies into live cells and is expressed in the BBB. PAT-DX1 (also known as Deoxymab-1 or DX1) is an ENT2-dependent, cell-pene...

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Veröffentlicht in:Neurooncol Adv
Hauptverfasser: Rattray, Zahra, Deng, Gang, Zhang, Shenqi, Shirali, Anupama, May, Christopher, Liu, Jun, Zou, Pan, Cuffari, Benedette, Rattray, Nicholas, Johnson, Caroline, Dubljevic, Valentina, Campbell, James, Huttner, Anita, Baehring, Joachim, Zhou, Jiangbing, Hansen, James
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2020
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Supplement Abstracts
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7401412/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/noajnl/vdaa073.051
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