Srebp-1c/Fgf21/Pgc-1α Axis Regulated by Leptin Signaling in Adipocytes—Possible Mechanism of Caloric Restriction-Associated Metabolic Remodeling of White Adipose Tissue

Caloric restriction (CR) improves whole body metabolism, suppresses age-related pathophysiology, and extends lifespan in rodents. Metabolic remodeling, including fatty acid (FA) biosynthesis and mitochondrial biogenesis, in white adipose tissue (WAT) plays an important role in the beneficial effects...

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Veröffentlicht in:Nutrients
Hauptverfasser: Kobayashi, Masaki, Uta, Seira, Otsubo, Minami, Deguchi, Yusuke, Tagawa, Ryoma, Mizunoe, Yuhei, Nakagawa, Yoshimi, Shimano, Hitoshi, Higami, Yoshikazu
Format: Artigo
Sprache:Inglês
Veröffentlicht: MDPI 2020
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7400870/
https://ncbi.nlm.nih.gov/pubmed/32664386
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/nu12072054
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