NuRD mediates mitochondrial stress–induced longevity via chromatin remodeling in response to acetyl-CoA level

Mild mitochondrial stress experienced early in life can have beneficial effects on the life span of organisms through epigenetic regulations. Here, we report that acetyl–coenzyme A (CoA) represents a critical mitochondrial signal to regulate aging through the chromatin remodeling and histone deacety...

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Detalhes bibliográficos
Publicado no:Sci Adv
Main Authors: Zhu, Di, Wu, Xueying, Zhou, Jun, Li, Xinyu, Huang, Xiahe, Li, Jiasheng, Wu, Junbo, Bian, Qian, Wang, Yingchun, Tian, Ye
Formato: Artigo
Idioma:Inglês
Publicado em: American Association for the Advancement of Science 2020
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7400466/
https://ncbi.nlm.nih.gov/pubmed/32789178
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.abb2529
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